12.31.2004

2004 - New GP - Ketoconazole

08-Jan-04
Last EDTA

21-Jan-04
PSA= 2.18

27-Jan-04
new GP: Dr G. Seward
Examined & Blood Work
Glucose-Fasting =5.4 (3.9 - 6.0)
Cholesterol = 7.15 HI (Elevated Risk > 6.20)
LDL Cholesterol = 5.07 HI
HDL-Cholesterol = 1.38 (1.17 - 1.55)
Cholesterol/HDL Ratio = 5.2 HI
Triglycerides = 1.53 mmol/L10

28-Jan-04
Stop Lupron 28 Day, Start Lupron 84 Day. (given wrong Rx by stand-in onco)

10-Feb-04
Start Crestor 10mg once daily

25-Feb-04
PSA= 2.215

Mar-04 Event:
ThoracicPain begins.

22-Mar-04
Dr G. Seward orders Thoracic X-Rays

25-Mar-04 Diag:
BMD test - TGH
Report:


DIAGNOSTIC IMAGING CLINICAL CONSULTATION
REPORT: X-R THORACIC SPINE 2 VIEWS; "There
is a moderately severe kyphosis with a moderate scoliosis convex to the
right. There is considerable calcification of the anterior
longitudinal ligament. This involves the entire thoracic spine and
portions of the upper lumbar spine. The appeatance is suggestive of
ankylosing spondylitis. There is also noted to be a moderate degree of
osteoporosis of the thoracic vertebra. I could see no evidence
of any osteolytic or osteoblastic change consistent with metastatic
disease. The examination is otherwise,
unremarkable. Pain since relieved with Chiropractic care.


26-Mar-04
PSA= 2.2

14-Apr-04
PSA= 2.52
STOP Casodex 50mg

17-May-04
PSA= 4.4

07-Jun-04
PSA= 6.8

09-Jul-04
Mt. Sinai Hosp: Nuclear Medicine:
Planar Images of total Body Bone Scan and Blood Flow/Pool study(Comparison Sept 17, 2003)


Findings: There is no significant change from the previous
study. The previously noted faint foci of activity at the left LS-SI
region and right SI joint have not significantly changed.No other significant
abnormality is seen.

Impression: Findings are likely secondary to degenerative change. No definite evidence of axial or appendicular skeletal metastases seen.



14-Jul-04
PSA= 7.99
FreePSA 0.39;
PSA Ratio= 0.05;
T=0.8

14-Jul-04
STOP Lupron 84 day. START Lupron 28 day (requested by patient)

15-Jul-04
START Ketoconazole 200mg t.i.d. (LDK)
START Hydrocortisone 20mg q. a.m.; 10mg q. p.m.

16-Aug-04
PSA= 4.1
Liver Enzymes "normal range" Verbal report - (denied written report).

08-Sep-04
PSA= 4.1

13-Oct-04
PSA= 3.55

25-Oct-04
Dr Seward (GP) BP 180/70 - told to minimize sodium intake - will try to get appointment with Dr Hess (Cardio.)

29-Oct-04
Dr Seward (GP) visit to check-up on elevated BP 160/70
Rx for Beta Blocker. Dr. thinks the steroid is causing sodium retention and effecting BP

30-Oct-04
STOP HC 20mg in am
START HC 17.5mg in am

03-Nov-04
STOP HC 17.5mg in am
START HC 15mg in am

04-Nov-04
START Metopronol tartrate 25mg bid

04-Nov-04
Fax Dr Tannock re withdrawal of HC and question Angiotensin II blockers in
place of Metopronol taartrate.

07-Nov-04
Phone call from Dr Tannock agreed with reduction of HC "as long as no symptoms"
Said Angiotensin studies I sent were "Fuzzy" and that some studies show it is the Angiotensin itself that has some effect against PCa and the "Blockers may do just the opposite" He did not feel that either class of drug would "significantly effect Gord's PCa one way or another"

07-Nov-04
STOP HC 15mg in am
START HC 12.5mg in am

09-Nov-04
PSA = 3.39

10-Nov-04
STOP HC 12.5mg in am
START HC 10mg in am

07-Dec-04
PSA = 3.29
Continue on Keto 200mg t.i.d. with HC 10mg b.i.d.